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paquinimod rescue assay  (TargetMol)


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    TargetMol paquinimod rescue assay
    <t>Paquinimod</t> rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 μm. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 μm. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were significantly decreased by Paquinimod treatment. n = 3. (H) Heatmap depicting a decrease in B cell-related gene expression in the lungs of mice infected with SARS-CoV-2. (I) qRT-PCR analysis for the expression of B cell marker gene Cd19 in the peripheral blood of mice infected with SARS-CoV-2 after Paquinimod treatment. n ≥ 5. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. Error bars, SD.
    Paquinimod Rescue Assay, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/paquinimod rescue assay/product/TargetMol
    Average 93 stars, based on 4 article reviews
    paquinimod rescue assay - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19"

    Article Title: Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

    Journal: Cell Host & Microbe

    doi: 10.1016/j.chom.2020.12.016

    Paquinimod rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 μm. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 μm. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were significantly decreased by Paquinimod treatment. n = 3. (H) Heatmap depicting a decrease in B cell-related gene expression in the lungs of mice infected with SARS-CoV-2. (I) qRT-PCR analysis for the expression of B cell marker gene Cd19 in the peripheral blood of mice infected with SARS-CoV-2 after Paquinimod treatment. n ≥ 5. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. Error bars, SD.
    Figure Legend Snippet: Paquinimod rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 μm. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 μm. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were significantly decreased by Paquinimod treatment. n = 3. (H) Heatmap depicting a decrease in B cell-related gene expression in the lungs of mice infected with SARS-CoV-2. (I) qRT-PCR analysis for the expression of B cell marker gene Cd19 in the peripheral blood of mice infected with SARS-CoV-2 after Paquinimod treatment. n ≥ 5. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. Error bars, SD.

    Techniques Used: Infection, Staining, Immunohistochemical staining, Quantitative RT-PCR, Expressing, Flow Cytometry, Marker


    Figure Legend Snippet:

    Techniques Used: Recombinant, Lysis, Expressing, Software



    Similar Products

    paquinimod rescue assay  (TargetMol)
    93
    TargetMol paquinimod rescue assay
    <t>Paquinimod</t> rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 μm. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 μm. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were significantly decreased by Paquinimod treatment. n = 3. (H) Heatmap depicting a decrease in B cell-related gene expression in the lungs of mice infected with SARS-CoV-2. (I) qRT-PCR analysis for the expression of B cell marker gene Cd19 in the peripheral blood of mice infected with SARS-CoV-2 after Paquinimod treatment. n ≥ 5. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. Error bars, SD.
    Paquinimod Rescue Assay, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/paquinimod rescue assay/product/TargetMol
    Average 93 stars, based on 1 article reviews
    paquinimod rescue assay - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    Paquinimod rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 μm. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 μm. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were significantly decreased by Paquinimod treatment. n = 3. (H) Heatmap depicting a decrease in B cell-related gene expression in the lungs of mice infected with SARS-CoV-2. (I) qRT-PCR analysis for the expression of B cell marker gene Cd19 in the peripheral blood of mice infected with SARS-CoV-2 after Paquinimod treatment. n ≥ 5. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. Error bars, SD.

    Journal: Cell Host & Microbe

    Article Title: Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

    doi: 10.1016/j.chom.2020.12.016

    Figure Lengend Snippet: Paquinimod rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 μm. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 μm. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were significantly decreased by Paquinimod treatment. n = 3. (H) Heatmap depicting a decrease in B cell-related gene expression in the lungs of mice infected with SARS-CoV-2. (I) qRT-PCR analysis for the expression of B cell marker gene Cd19 in the peripheral blood of mice infected with SARS-CoV-2 after Paquinimod treatment. n ≥ 5. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. Error bars, SD.

    Article Snippet: For the Paquinimod rescue assay, all mice were challenged by viruses and randomly divided into two groups, in which one group was given intranasally 12.5 μg/day of Paquinimod (TargetMol; Catalog No. T7310) starting on 2 dpi and the other group was treated with equal volume PBS as the control group.

    Techniques: Infection, Staining, Immunohistochemical staining, Quantitative RT-PCR, Expressing, Flow Cytometry, Marker

    Journal: Cell Host & Microbe

    Article Title: Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

    doi: 10.1016/j.chom.2020.12.016

    Figure Lengend Snippet:

    Article Snippet: For the Paquinimod rescue assay, all mice were challenged by viruses and randomly divided into two groups, in which one group was given intranasally 12.5 μg/day of Paquinimod (TargetMol; Catalog No. T7310) starting on 2 dpi and the other group was treated with equal volume PBS as the control group.

    Techniques: Recombinant, Lysis, Expressing, Software